Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats

Objective(s) This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. Materials and Methods Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total c...

متن کامل

Sterol carrier protein2. Delivery of cholesterol from adrenal lipid droplets to mitochondria for pregnenolone synthesis.

The ability of sterol carrier protein2 (SCP2) to mediate transfer of unesterified cholesterol from adrenal lipid inclusion droplets to mitochondria has been tested in an in vitro model system. Unlike mitochondrial utilization of cholesterol added in acetone or dimethyl sulfoxide, the unesterified cholesterol of lipid droplets did not provide a readily available source of substrate for mitochond...

متن کامل

Lipid droplets

OK, they are cute, but why should a developmental biologist care about them? Onset of calcification early in ontogeny coupled with gradual, progressive morphological development permits the recognition of growth sequences for over a hundred trilobite species. Striking variation in the number of trunk segments at maturity across ontogeny and phylogeny, coupled with the curious pattern of segment...

متن کامل

Expanding Roles for Lipid Droplets

Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid metabolism and energy homeostasis, and their dysfunction has been linked to many diseases. Accumulating evidence suggests that the roles lipid droplets play in biology are significantly broader than previously anticipated. Lipid droplets are the source of molecules important in the nucleus: they ca...

متن کامل

Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides.

Dendrimer-based gene delivery has been constrained by intrinsic toxicity and suboptimal nanostructure. Conjugation of neutral morpholino oligonucleotides (ONs) with PAMAM dendrimers resulted in neutral, uniform, and ultra-small (∼10 nm) nanoconjugates. The nanoconjugates dramatically enhanced cellular delivery of the ONs in cancer cells. After release from the dendrimer in the cytosol, the ONs ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biomaterials

سال: 2011

ISSN: 0142-9612

DOI: 10.1016/j.biomaterials.2010.10.025